NASA’s Human Research Program (HRP) partners with external entities in researching and developing innovative approaches to reduce risks to humans on long-duration exploration missions, including NASA’s Journey to Mars. One of these partnerships is the Translational Research Institute for Space Health (TRISH), a cooperative agreement with a consortium led by Baylor College of Medicine and includes the California Institute of Technology in Pasadena and Massachusetts Institute of Technology in Cambridge. The mission of the TRISH is to lead a national effort in translating cutting edge emerging terrestrial biomedical research and technology development into applied space flight human risk mitigation strategies for human exploration missions.